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Though vaccines are necessary to keep your dog from getting potentially deadly infectious diseases, unfortunately, they do sometimes come with side effects. Common mild reactions to vaccines include soreness and swelling at the location of the vaccine shot, mild fever, lethargy, and sneezing. More serious, but rare reactions include life threatening allergic reactions and the development of a tumor or sarcoma at the location of the shot.
If your canine experiences any side effects due to a vaccine, your best option is to make a note of the symptoms and discuss it with your veterinarian prior to your dog's next set of shots.