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If you find your normally voracious canine has lost his appetite, there may be some cause for concern. Loss of appetite is one of the first signs of illness. Your canine could also be experiencing pain of some sort and therefore refuse to eat. Or it could be possible that your dog has a loss of appetite due to a change in environment such as a new pet or introduction to new food. However, to be safe, if you've ruled out any behavioral issues, take your pooch to the veterinarian for a proper diagnosis.