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You should always ask a few questions to make sure you're dealing with a conscientious breeder.
1.Ask the breeder for a history on the sire and dam of the puppy. Reputable breeders will screen the breeding pair for any genetic deficiencies.
2. Has the puppy had a veterinary examination and is she current on all her shots?
3. Where does the puppy spend its time during the day and is she being socialized?
4. Does the breeder have references of previous dog owners and is she willing to provide them to you?