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While some veterinarians recommend giving a puppy some of its first shots at six weeks of age, many recommend doing so at eight weeks, with more at 12 weeks, 16 weeks, and 20 weeks. The first shots are typically for parvovirus, hepatitis, distemper, parainfluenza, and Lyme disease. Some shots do vary by region and schedules may vary according to your vet's recommendations. Be sure to talk with your own vet about a preferred schedule for your puppy.